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Patch and method for producing the same
专利权人:
Hisamitsu Pharmaceutical Co.; Inc.
发明人:
Naruhito Higo,Tetsurou Tateishi,Takaaki Terahara,Kazunosuke Aida,Shigeki Hayashi,Nobuo Tsutsumi
申请号:
US13772843
公开号:
US08802134B2
申请日:
2013.02.21
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A method for producing a patch having a high skin penetrability and a high pharmaceutical physical properties such as adhesion and cohesiveness, and a long-term storability. The patch is produced by first obtaining an adhesive agent layer composition containing oxybutynin and/or salt thereof as a drug, an acrylic-based polymer and/or a rubber-based polymer as an adhesive base agent, liquid paraffin, an organic acid, and a tackifier; heating the adhesive agent layer composition at a temperature in a range from a melting point of the drug to a temperature higher than the melting point by 10° C. for 2 to 24 hours; and slowly cooling the heated adhesive agent layer composition to obtain the adhesive agent layer comprising the drug at a supersaturated concentration in a dissolved form.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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