The present invention provides a transdermal delivery system comprising: i. a drug-containing matrix layer comprising: methylphenidate base an adhesive polymer made up of a styrene rubber block copolymer having a styrene content of 24 % or above by weight of the adhesive polymer, the adhesive polymer is present in an amount of 20 % to 45 % by weight of the drug-containing matrix layer a tackifier present in an amount of 30 % to 45 % by weight of the drug-containing matrix layer a hydrocarbon plasticizer present in an amount of 1 % to 30 % by weight of the drug-containing matrix layer ii. a release liner and iii. a backing layer. The prior art marketed transdermal delivery systems or patches of methylphenidate presents with the problem of patch locking, i.e. the release liner is not easily removable from the product. Further, issues such as irritation, reddening and sensitization of skin during the treatment duration have been reported. Furthermore, the patient experiences pain upon removal of the patch. The present inventors have engineered a novel transdermal delivery system of methylphenidate which overcomes these problems. The present inventors have developed a transdermal delivery system of methylphenidate with desirable patch characteristics such as balanced tack, adhesion, cohesion and plasticity.
