您的位置: 首页 > 农业专利 > 详情页

Vector based vaccine HVT (herpes virus of Turkeys () against Newcastle Disease (ND) - Enhanced IBD (Infectious Bursal disease)
专利权人:
INTERVET INTERNATIONAL B.V.
发明人:
申请号:
ARP150104255
公开号:
AR103245A1
申请日:
2015.12.22
申请国别(地区):
AR
年份:
2017
代理人:
摘要:
The recombinant HVT Vaccine can be used for Poultry, which exhibited good Replication, viral vector, effective expression of NDV F Gene and VP2 of IBDV, inmunoprotecci u00f3n improved against ND and IBD, and Genetic stability improved with respect to the constructs of the State The Technique.Claim 1: a recombinant DNA expression cassette comprising from 5 to 3 direction and in this order: (a) a promoter of the murine cytomegalovirus immediate Early Gene 1 (AR1 MCMV -), (b) a Gene of the viral Protein (VP2) of Infectious Bursal disease virus (IBDV), C a Terminator) (d) a transcriptional Promoter 1 immediate Early Gene of Human cytomegalovirus (HCMV IE1, -)(e) a Gene of the fusion protein (f) of Newcastle Disease Virus (NDV). Claim 3: a recombinant DNA Molecule expression cassette comprising the recombinant DNA according to claim 1 or 2.Claim 2: herpes virus of Turkeys (HVT) recombinant expression cassette comprising a recombinant DNA according to claim 1 or 2, for which the expression cassette is inserted in the region of the Genome of the recombinant HVT US.Claim 7: vaccine for Poultry, comprising a recombinant HVT according to claim 4, and / or a host Cell according to claim 5, and a pharmaceutically acceptable Carrier.Claim 13: a method to prevent or reduce Infection and / or NDV or IBDV, The Associated signs of the disease, where the method comprises the Administration of a vaccine according to claim 7 or 8 to Poultry.El HVT recombinante puede utilizarse en una vacuna para aves de corral, el cual exhibió buena replicación vectorial viral, expresión eficaz de los genes F de NDV y VP2 del IBDV, inmunoprotección mejorada contra ND e IBD, y estabilidad genética mejorada con respecto a los constructos del estado de la técnica. Reivindicación 1: Un casete de expresión de ADN recombinante que comprende en dirección de 5 a 3 y en este orden: a) un promotor del gen temprano inmediato 1 de citomegalovirus murino (mCMV-IE1), b) un gen de la proteína viral (VP2) del virus
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充