recombinant DNA expression cassette, recombinant DNA molecule, recombinant turkey herpes virus, host cell, methods for constructing a recombinant turkey herpes virus, for preparing a vaccine, to prevent or reduce infectious bursal disease virus infection, and / or newcastle disease virus or associated signs of bird disease and vaccination, bird vaccine, and uses of an expression cassette and a vaccine.
IWAN VERSTEGEN,PAUL VERMEIJ,PAULUS JACOBUS ANTONIUS SONDERMEIJER
申请号：
BR112017013595
公开号：
BR112017013595A2
申请日:
2015.12.23
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
The present invention relates to a novel and improved hvt vectorized nd-ibd vaccine comprising a recombinant hvt comprising the ibdv vp2 gene and the ndv f gene to an animal target. recombinant hvt can be used in a bird vaccine, which has good viral vector replication, effective expression of the ibdv ndv and vp2 f gene, improved nd and ibd immunoprotection, and improved genetic stability over prior art constructs.a presente invenção se refere a uma vacina de nd-ibd vetorizada com hvt nova e melhorada compreendendo um hvt recombinante compreendendo o gene vp2 de ibdv e o gene f de ndv a um alvo animal. o hvt recombinante pode ser usado em uma vacina para aves, que apresenta boa replicação viral do vetor, efetiva expressão do gene f de ndv e vp2 de ibdv, imunoproteção melhorada contra nd e ibd e estabilidade genética melhorada sobre os construtos do estado da técnica.
