University of Maryland, Baltimore;GPB Scientific, LLC;The Trustees of Princeton University
发明人:
WARD, Anthony,CAMPOS-GONZALEZ, Roberto,SKELLEY, Alison,GANDHI, Khushroo,GRISHAM, Michael,CIVIN, Curt,STURM, James C.
申请号：
AU2018323875
公开号：
AU2018323875A1
申请日:
2018.08.22
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention is directed to the use of microfluidics in the preparation of cells and compositions for therapeutic uses. In its first aspect, the invention is directed to a method of genetically engineering a population of target cells. This is done by isolating the target cells from a crude fluid composition by performing Deterministic Lateral Displacement (DLD) on a microfluidic device. The invention includes a method of producing CAR T cells by obtaining a crude fluid composition comprising T cells and performing DLD on the composition using a microfluidic device. In another aspect, the invention is directed to a method of treating a patient for cancer, an autoimmune disease or an infectious disease by administering CAR T cells engineered according to the method.
