GPB SCIENTIFIC, LLC;THE TRUSTEES OF PRINCETON UNIVERSITY;UNIVERSITY OF MARYLAND, BALTIMORE
发明人:
WARD, ANTHONY,CAMPOS-GONZALEZ, ROBERTO,SKELLEY, ALISON,GANDHI, KHUSHROO,GRISHAM, MICHAEL,CIVIN, CURT,STURM, JAMES C.
申请号：
CA3041522
公开号：
CA3041522A1
申请日:
2017.10.23
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention is directed to the use of Deterministic Lateral Displacement (DLD) in the preparation of cells and compositions for therapeutic uses. The present invention is directed, inter alia, to methods of collecting and rapidly processing cells, particularly cells that have therapeutic uses. The invention is directed to a method of genetically engineering a population of target cells comprising isolating target cells from a crude fluid composition by performing DLD using a microfluidic device. The invention includes a method of producing CAR T cells by obtaining a crude fluid composition comprising T cells.
