ARCHAKOV, ALEXANDR IVANOVICH,GUSEVA, MARIYA KIRILLOVNA,UCHAYKIN, VASILY FEDOROVICH,IPATOVA, OLGA MIKHAYLOVNA,DOCHSHITSIN, YURY FEDOROVICH,TIKHONOVA, YELENA GEORGIYEVNA,MEDVEDEVA, NATALYA VELORIKOVNA,P
申请号：
EP10772313
公开号：
EP2431038A4
申请日:
2010.04.07
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
The invention relates to the fields of medicine and pharmacology and concerns a storage-stable composition made up of nanoparticles which are based on vegetable phospholipids and contain the antiviral drug Arbidol. The aim of the present invention is to develop a non-fatty phospholipid composition of Arbidol in which the micellar and liposomal particles have an average diameter of 8-25 nm, and which has low toxicity, can be stored for long periods and is capable of transporting the medicinal agent in the body and ensuring the high bioaccessibility of said agent. This aim is achieved by a phospholipid composition of Arbidol in the form of phospholipid nanoparticles with a size of 8-25 nm, which contains phosphatidylcholine, maltose and Arbidol in the following component ratio: 20-43 mass% phosphatidylcholine 55-78 mass% maltose 2-8 mass% Arbidol.
