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Data from: TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephal
- 负责人：
- Kurimoto, Emi
- 关键词：
- Monkeys Cognitive impairment Alzheimer's disease Electroencephalography Biomarkers Animal cognition Cholinergics Oral administration
- DOI：
- doi:10.5061/dryad.qp313np
- 摘要：
- ’s disease, dementia with Lewy bodies, and schizophrenia. TAK-071 is an M1-selective positive allosteric modulator that improves cognitive deficits induced
Mouse lemur reference genome and diversity panel.
- 负责人：
- BGI
- DOI：
- doi:10.26036/cnphis0001816
- 摘要：
- d as animal models for various studies related to human biology and disease, including aging, reproductive biology and Alzheimer''s disease.
Data from: INTREPAD: a randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.r58d342
- 摘要：
- -symptomatic Alzheimer Progression Score (APS). Results: Safety: Naproxen-treated individuals showed a clear excess of adverse events. Efficacy: Amo
Data from: Leptin regulation of hippocampal synaptic function in health and disease
- 负责人：
- DOI：
- doi:10.5061/dryad.n8f46
- 摘要：
- h as Alzheimer's disease (AD). Here, we review the evidence supporting a cognitive enhancing role for the hormone leptin and discuss the therapeutic potential of using leptin
Data from: The Golgi-localized ?-ear-containing ARF-binding (GGA) proteins alter amyloid-? precursor protein (APP) processing through inter
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.7qm89
- 摘要：
- of amyloid beta (A?), which accumulates in senile plaques in Alzheimer’s disease (AD). Essential for this cleavage is the transport and sorting of both proteins thr
Data from: The N-end Rule Pathway and Ubr1 enforce protein compartmentalization via P2-encoded cellular location signals
- 负责人：
- DOI：
- doi:10.5061/dryad.r837vv7
- 摘要：
- and the N-end rule pathway are involved in neurodegenerative diseases such as Alzheimer's and Parkinson's. A corollary to this discovery is that the N-end rule
Study of Dementia in Swedish Twins, 1990-1999;;Archival Version
- 负责人：
- 关键词：
- DOI：
- doi:10.3886/icpsr25963
- 摘要：
- The Study of Dementia in Swedish Twins was designed to study the relative influence of genetic and environmental factors for Alzheimer's disease
Data from: Abnormal CSF amyloid-?42 and tau levels in hip fracture patients without dementia
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.sb7nb51
- 摘要：
- Background: There is strong association of Alzheimer's disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal
Data from: Elovanoids counteract oligomeric ?-Amyloid-induced gene expression and protect photoreceptors
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.59zw3r233
- 摘要：
- th and impairments in cognition (Alzheimer’s disease, AD) and sight (age-related macular degeneration, AMD). How neuroinflammation can be counter
Data from: Cognition at age 70: life course predictors and associations with brain pathologies
- 负责人：
- DOI：
- doi:10.5061/dryad.nt561v7
- 摘要：
- Objective: To investigate predictors of performance on a range of cognitive measures including the Preclinical Alzheimer Cognitive Composite (PACC
