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共检索到38条 ,权限内显示50条;
Data from: Functional amyloids promote retention of public goods in bacteria
- 负责人：
- DOI：
- doi:10.5061/dryad.v8c8h23
- 摘要：
- -scavenging molecule pyoverdine, and hence reduce the potential for exploitation by non-producing, cheating cells. We found that: (1) wildtype cells retain mor
Studies of intracellular cascades mediating neuronal damage in two animal models of neurodegeneration
- 负责人：
- DOI：
- doi:10.25549/usctheses-c3-335637
- 摘要：
- Alzheimer\u2019s disease is characterized by progressive memory loss and cognitive deficits, accumulation of ?-amyloid plaques and intracellular
Data from: Microglial activation in early Alzheimer trajectory is associated with higher grey matter volume
- 负责人：
- DOI：
- doi:10.5061/dryad.6mp3r21
- 摘要：
- correlations and biological parametric mapping analysis. Amyloid status was assessed using [18F]Flutemetamol PET. Results: Higher [11C]PBR28 VT in different
Data from: Revisiting protein aggregation as pathogenic in sporadic Parkinson’s and Alzheimer’s diseases
- 负责人：
- Espay, Alberto J.
- 关键词：
- Parkinson’s disease Alzheimer’s disease biomarkers disease modifying treatments clinical trials
- DOI：
- doi:10.5061/dryad.g1nq02r
- 摘要：
- and for Alzheimer’s disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinico-pathologic-based nosology
Data from: Abnormal CSF amyloid-?42 and tau levels in hip fracture patients without dementia
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.sb7nb51
- 摘要：
- Background: There is strong association of Alzheimer's disease (AD) pathology with gait disorder and falls in older adults without dementia. The goal of the study was to examine the prevalence and severity of AD pathology in older adults without dementia who fall and sustain hip fracture. Methods: Cerebrospinal fluid (CSF) was obtained from 168 hip fracture patients. CSF A?42/40 ratio, p-tau, and t-tau measures were dichotomized into normal vs. abnormal, and categorized according to the A/T/N classification. Results: Among the hip fracture patients, 88.6% of the cognitively normal (Clinical Dementia Rating-CDR 0; n=70) and 98.8% with mild cognitive impairment (CDR 0.5; n=81) fell in the abnormal biomarker categories by the A/T/N classification. Conclusions: A large proportion of older hip fracture patients have CSF evidence of AD pathology. Preoperative determination of AD biomarkers may play a crucial role in identifying persons without dementia who have underlying AD pathology in perioperative settings.
Data from: Increased CAIDE dementia risk, cognition, CSF biomarkers and vascular burden in healthy adults
- 负责人：
- DOI：
- doi:10.5061/dryad.0f454q8
- 摘要：
- ) and CSF (n = 218) levels of amyloid-?1-42 (A?1-42), total tau (t-tau) and phosphorylated tau (p-tau) in the association between CAIDE and cognition
Data from: CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer's disease
- 负责人：
- DOI：
- doi:10.5061/dryad.5f82b32
- 摘要：
- changes and study their associations with the core biomarkers of AD pathology (amyloid &[beta] (A&[beta]) and tau), structural imaging correlates
Data from: A?42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism
- 负责人：
- DOI：
- doi:10.5061/dryad.7n4c218
- 摘要：
- y adopt a different structure from fibrils formed by smaller oligomers, pointing to a link between oligomer heterogeneity and fibril polymorphism.
Dataset for research paper: α-Synuclein Increases β-Amyloid Secretion by Promoting β-\/γ-Secretase Processing of APP
- 负责人：
- University Of Bath
- DOI：
- doi:10.15125/bath-00310
- 摘要：
- -1, Amyloid Precursor Protein β-Secretase Inhibitor (βSI), and β-Secretase Inhibitor IV (βIV) were purchased from Merck Millipore. DAPT was purchased from Tocris. TAPI, βSI, βIV
Data from: Sex differences in CSF biomarkers vary by Alzheimer’s disease stage and APOE epsilon 4 genotype
- 负责人：
- DOI：
- doi:10.5061/dryad.ttdz08ktw
- 摘要：
- ) and Subjective Cognitive Decline (SCD; n=427). Main outcomes were CSF amyloid ?1-42 (A?42), total tau (Tau) and tau phosphorylated at threonine 181 (pTau) levels
