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共检索到38条 ,权限内显示50条;
Data from: The Golgi-localized ?-ear-containing ARF-binding (GGA) proteins alter amyloid-? precursor protein (APP) processing through interaction
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.7qm89
- 摘要：
- Proteolytic processing of amyloid-? precursor protein (APP) by beta-site APP cleaving enzyme 1 (BACE1) is the initial step in the production
Data from: A mix-and-click method to measure amyloid-? concentration with sub-micromolar sensitivity
- 负责人：
- DOI：
- doi:10.5061/dryad.7mg3h
- 摘要：
- Aggregation of amyloid-? (A?) protein plays a central role in Alzheimer's disease. Because protein aggregation is a concentration-dependent process
Data from: Site-specific structural order in Alzheimer’s A?42 fibrils
- 负责人：
- DOI：
- doi:10.5061/dryad.768dk4s
- 摘要：
- Deposition of amyloid fibrils is a pathological hallmark of Alzheimer’s disease. A?42 is the major protein whose aggregation leads to the formation
Data from: Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
- 负责人：
- DOI：
- doi:10.5061/dryad.174667c
- 摘要：
- e unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced transcripts in digestive
Data from: Natural history and survival in stage 1 Val30Met transthyretin familial amyloid polyneuropathy
- 负责人：
- DOI：
- doi:10.5061/dryad.3583v22
- 摘要：
- Objectives: To assess natural history and treatment effect on survival among transthyretin-associated familial amyloid polyneuropathy (TTR-FAP
Noscapine Treatment Effect In Transgenic Mouse Model Of Alzheimer'S Disease
- 负责人：
- 关键词：
- Alzheimer's disease Transgenic mouse Magnetic resonance imaging Cerebral vascular reactivity Cerebral blood flow Cerebrovascular dysfunction
- DOI：
- doi:10.5281/zenodo.1209064
- 摘要：
- involving bradykinin receptor has been proposed at the nexus of beta-amyloid, vascular pathology and inflammation in patients with AD and in animal models
Noscapine Treatment Effect In Transgenic Mouse Model Of Alzheimer'S Disease
- 负责人：
- 关键词：
- Alzheimer's disease Transgenic mouse Magnetic resonance imaging Cerebral vascular reactivity Cerebral blood flow Cerebrovascular dysfunction
- DOI：
- doi:10.5281/zenodo.1209065
- 摘要：
- involving bradykinin receptor has been proposed at the nexus of beta-amyloid, vascular pathology and inflammation in patients with AD and in animal models
Data from: Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy
- 负责人：
- DOI：
- doi:10.5061/dryad.rb9665d
- 摘要：
- Objective: To investigate the prognostic relevance of cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA
Data from: Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with DTI MRI
- 负责人：
- DOI：
- doi:10.5061/dryad.121hs31
- 摘要：
- The glymphatics system describes a CSF-mediated clearance pathway for the removal of potentially harmful molecules, such as amyloid beta, from
Data from: An MRI measure of degenerative and cerebrovascular pathology in Alzheimer’s disease
- 负责人：
- DOI：
- doi:10.5061/dryad.m8s3r88
- 摘要：
- and validated using autopsy data, clinical diagnoses, and cerebrospinal fluid biomarkers and amyloid PET from the Alzheimer’s Disease Neuroimaging Initiative
