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Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical species variants for fibrillization
- 负责人：
- 关键词：
- Information and Computing Sciences Biological Sciences Ecology Chemistry Earth and Environmental Sciences Molecular Biology Biochemistry Biophysics
- DOI：
- doi:10.6084/m9.figshare.1568456.v1
- 摘要：
- Amyloid can be detected in the islets of Langerhans in a majority of type 2 diabetic patients. These deposits have been associated with β-cell death
Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical species variants for fibrillization
- 负责人：
- 关键词：
- Biophysics Biochemistry Molecular Biology 59999 Environmental Sciences not elsewhere classified 39999 Chemical Sciences not elsewhere classified 69999 Biological Sciences not elsewhere classified 80699 Information Systems not elsewhere classified
- DOI：
- doi:10.6084/m9.figshare.1568456
- 摘要：
- Amyloid can be detected in the islets of Langerhans in a majority of type 2 diabetic patients. These deposits have been associated with β-cell death
Data from: Serum amyloid A protein concentration in blood is influenced by genetic differences in the cheetah (Acinonyx jubatus)
- 负责人：
- DOI：
- doi:10.5061/dryad.0nr72
- 摘要：
- Systemic amyloid A (AA) amyloidosis is a major cause of morbidity and mortality among captive cheetahs. The self-aggregating AA protein responsible
Data from: Total A?42/A?40 ratio in plasma predict amyloid-PET status, independent of clinical AD diagnosis
- 负责人：
- DOI：
- doi:10.5061/dryad.f300d56
- 摘要：
- pathology prior to ordering the CSF and PET testing. Objective: To explore if the plasma total A?42/A?40 ratio is a reliable predictor of the amyloid-PET
Data from: Brain myo-inositol as a potential marker of amyloid-related pathology: a longitudinal study.
- 负责人：
- DOI：
- doi:10.5061/dryad.rd681sp
- 摘要：
- Objective: To investigate the association between longitudinal changes in proton magnetic spectroscopy (MRS) metabolites and amyloid pathology
Data from: ATN profiles among cognitively normal individuals and longitudinal cognitive outcomes
- 负责人：
- DOI：
- doi:10.5061/dryad.88br3tn
- 摘要：
- Objective. The amyloid/tau/neurodegeneration (ATN) research framework for Alzheimer’s disease (AD) was proposed to organize AD biomarkers
Data from: Association of years to parent’s sporadic onset and risk factors with neural integrity and Alzheimer’s biomarkers
- 负责人：
- DOI：
- doi:10.5061/dryad.280gb5mn1
- 摘要：
- , vascular and mental health. Results: Proximity to parental AAO was associated with ?-amyloid, but not with neural injury biomarkers, and interacted
Data from: Amyloid and cerebrovascular burden divergently influence brain functional network changes over time
- 负责人：
- DOI：
- doi:10.5061/dryad.v5h2fd7
- 摘要：
- ; svMCI: 13 with two time-points, 16 with three time-points, 26 with four time-points). Results: Amyloid-? burden was associated with longitudinal DMN FC
Data from: Elovanoids counteract oligomeric ?-Amyloid-induced gene expression and protect photoreceptors
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.59zw3r233
- 摘要：
- is not known. In AMD, amyloid ?-peptide (A?) accumulates in subretinal drusen. In the 5xFAD retina, we found early functional deficiencies (ERG
Data from: Amyloid precursor protein translation is regulated by a 3'UTR guanine quadruplex
- 负责人：
- DOI：
- doi:10.5061/dryad.27g0v
- 摘要：
- A central event in Alzheimer’s disease is the accumulation of amyloid ? (A?) peptides generated by the proteolytic cleavage
