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共检索到42条 ,权限内显示50条;
Data from: Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors
- 负责人：
- DOI：
- doi:10.5061/dryad.4h76d
- 摘要：
- on. Our computational model can predict the in vivo targeting levels of the intracellular adhesion molecule-1 (ICAM1)-coated NCs targeted to the lung, heart, kidney, liver
Data from: A homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy
- 负责人：
- 关键词：
- DOI：
- doi:10.5061/dryad.kwh70rz04
- 摘要：
Objective: Facioscapulohumeral muscular dystrophy (FSHD) is a heterogenetic disorder pred
Proinsulin-transferrin fusion protein as a liver targeting insulin therapeutic in Type 1 diabetes treatment
- 负责人：
- 关键词：
- Pharmaceutical Sciences proinsulin-transferrin fusion protein liver targeting diabetes long-acting insulin therapeutic
- DOI：
- doi:10.25549/usctheses-c40-250950
- 摘要：
- s inherent to the s.c injection site and efficient liver targeting of INS are discussed and current advances in developing hepatoselective INS therapeutics ar
Data from: Controlling invasive rodents via synthetic gene drive and the role of polyandry
- 负责人：
- DOI：
- doi:10.5061/dryad.4g1t4ht
- 摘要：
- s been proposed as a means to eradicate target mouse populations due to a lack of females. A factor that has received little attention in the discussion surrounding
Data from: Selective breeding and selection mapping using a novel wild-derived heterogeneous stock mice revealed two closely-linked loci for tameness
- 负责人：
- DOI：
- doi:10.5061/dryad.36f3q
- 摘要：
- on in the target population, so we established and used a novel resource, wild-derived heterogeneous stock (WHS) mice from eight wild strains. The mice ha
Data from: Characterization of a novel fusion gene EML4-NTRK3 in a case of recurrent congenital fibrosarcoma
- 负责人：
- DOI：
- doi:10.5061/dryad.521j5
- 摘要：
- that multiple fusion partners targeting NTRK3 can contribute to the development of congenital fibrosarcoma.
Data from: Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse
- 负责人：
- DOI：
- doi:10.5061/dryad.mv34v
- 摘要：
- ed a high throughput, multi-parameter phenotype screen to the conditional targeted mutant mice generated by the Wellcome Trust Sanger Institute's Mouse Genetics Project
Data from: Aberrant activation of the RANK signaling receptor induces murine salivary gland tumors
- 负责人：
- DOI：
- doi:10.5061/dryad.qh3mm
- 摘要：
- in the salivary gland and suggest that targeting this pathway may represent a novel therapeutic intervention approach in the prevention and/or treatment
Data from: Tumor suppressor RARRES1- a novel regulator of fatty acid metabolism in epithelial cells
- 负责人：
- DOI：
- doi:10.5061/dryad.6t1m4k4
- 摘要：
- h as hepatic steatosis, hyperinsulinemia and obesity. Here we report a novel function of RARRES1 in metabolic reprogramming of epithelial cells. Using non-targeted LC-MS
Development of targeted therapies for peroxisome biogenesis disorders
- 负责人：
- 关键词：
- Molecular Biology peroxisome biogenesis disorders peroxins PEX1 high-content screening small molecules induced pluripotent stem cells HepG2 cells Pex1-p.G844D mouse
- DOI：
- doi:10.25549/usctheses-c40-298640
- 摘要：
- small molecules we identified could provide tools for investigating peroxisome biogenesis and novel leads for the development of targeted small molecule ther
