THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SER
发明人:
COLLINS PETER,LIANG BO,MUNIR SHIRIN,NUTT ANNE SCHAAP,BUCHHOLZ URSULA,MACKOW NATALIE,KWONG PETER,GRAHAM BARNEY,MCLELLAN JASON
申请号：
US202318162530
公开号：
US2023287055A1
申请日:
20230131
申请国别(地区):
US
年份:
2023
代理人:
摘要：
Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus。
