BARBERA BETANCOURT, ARIANA,DOMINGUEZ HORTA, MARIA DEL CARMEN,LORENZO PEREZ, NORAILYS,PADRON PALOMARES, GABRIEL RAMON,FALCON CAMA, VIVIANA,MENENDEZ VALDES, IVON
申请号：
CA2748493
公开号：
CA2748493C
申请日:
2009.12.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention is related with the field of the medicine, particularlywith theuse of an APL peptide or its analogues derived from the human heat shockprotein of60 kDa, for the manufacture of a pharmaceutical composition for the treatmentofCrohn's disease, ulcerative colitis and diabetes mellitus type 1. This peptideisbiodistributed into the gastrointestinal tract and also promotes the inductionof apoptosisin activated intestinal lamina propria and peripheral blood T cells ofpatients withCrohn's disease. Furthermore, this peptide induces apoptosis in mononuclearcells ofpatients with diabetes mellitus type 1.
