Richard Lee Nuccitelli,Pamela Nuccitelli,Joanne Lum,Kaying Lui,Brian Athos,Mark Kreis,Zachary Mallon,Jon Berridge
申请号：
US14805828
公开号：
US20150320999A1
申请日:
2015.07.22
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on size and type of a tumor to stimulate an immune response against the tumor and other tumors in a subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.
