Richard Lee Nuccitelli,Pamela S. Nuccitelli,Joanne Lum,Kaying Lui,Brian G. Athos,Mark P. Kreis,Zachary R. Mallon,Jon Berridge
申请号：
US16909948
公开号：
US20200315687A1
申请日:
2020.06.23
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.
