NUCCITELLI, Richard Lee,NUCCITELLI, Pamela,LUM, Joanne,LUI, Kaying,ATHOS, Brian,KREIS, Mark,MALLON, Zachary,BERRIDGE, Jon
申请号：
AU2017200080
公开号：
AU2017200080B2
申请日:
2017.01.06
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2017200080B220180222.pdf#####METHODS AND DEVICES FOR STIMULATING AN IMMUNE RESPONSE USING NANOSECOND PULSED ELECTRIC FIELDS ABSTRACT Nanosecond pulsed electric field (nsPEF) treatments of a tumor are used to cause the tumor to express calreticulin and stimulate an immune response against the tumor and other tumors in a subject. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject.
