The present invention provides a pharmaceutical composition for treating colorectal cancer in a subject in need thereof, which comprises a first agent comprising at least a Zhankuic acid D (ZhAD)； and a second agent comprising at least an Antroquinonol B (AnQB)； as well as each of them can be obtained from the extractions of a fruiting body or a mycelium ofAntrodia camphoratawherein the first agent and the second agent shows synergistic effect for use in the treatment of colorectal cancer or to prevent or to reduce the risk of a colorectal cancer metastasizing, compared to administration of the first agent or the second agent alone.一種用於治療結腸直腸癌之醫藥組合物，其為適用於治療罹患結腸直腸癌的個體，該醫藥組合物包含：第一藥劑，其至少包含樟菇酸D (ZhAD)；及第二藥劑，其至少包含安卓奎諾爾B (AnQB)；以及其等各自可獲自牛樟芝之子實體或菌絲體之萃取物，其中相較於單獨投與該第一藥劑或該第二藥劑，該第一藥劑及該第二藥劑用於治療結腸直腸癌、預防結腸直腸癌轉移、或降低結腸直腸癌轉移之風險顯示出協同效應。
