The present invention provides a pharmaceutical composition for treating Prostate cancer in a subject in need thereof, which comprises a first agent comprising at least a Anctin K(AnK)； and a second agent comprising at least an Antroquinonol B (AnQB)； as well as each of them can be obtained from the extractions of a fruiting body or a mycelium ofAntrodiacamphoratawherein the first agent and the second agent shows synergistic effect for use in the treatment of Prostate cancer or to prevent or to reduce the risk of a Prostate cancer metastasizing, compared to administration of the first agent or the second agent alone一種用於治療攝護腺癌之醫藥組合物，其為適用於治療罹患攝護腺癌的個體，該醫藥組合物包含：第一藥劑，其至少包含樟菇酸K (AnK)；及第二藥劑，其至少包含安卓奎諾爾B (AnQB)；以及其等各自可獲自牛樟芝之子實體或菌絲體之萃取物，其中相較於單獨投與該第一藥劑或該第二藥劑，該第一藥劑及該第二藥劑用於治療攝護腺癌、預防攝護腺癌轉移、或降低攝護腺癌轉移之風險顯示出協同效應。
