The present invention provides a pharmaceutical composition for treating breast cancer in a subject in need thereof, which comprises a first agent comprising at least a dehydroeburicoic acid (DeEA) and a second agent comprising at least an Antroquinonol B (AnQB) as well as each of them can be obtained from the extractions of a fruiting body or a mycelium ofAntrodiacamphoratawherein the first agent and the second agent shows synergistic effect for use in the treatment of breast cancer or to prevent or to reduce the risk of a breast cancer metastasizing, compared to administration of the first agent or the second agent alone.一種用於治療乳癌之醫藥組合物,其為適用於治療罹患乳癌的個體,該醫藥組合物包含:第一藥劑,其至少包含去氫齒孔酸(DeEA);及第二藥劑,其至少包含安卓奎諾爾B (AnQB);以及其等各自可獲自牛樟芝之子實體或菌絲體之萃取物,其中相較於單獨投與該第一藥劑或該第二藥劑,該第一藥劑及該第二藥劑用於治療乳癌、預防乳癌轉移、或降低乳癌轉移之風險顯示出協同效應。無。