An article 100 comprising at least one microneedle 160 is provided. The article includes a first surface 112 and a second surface 114 opposite to the first surface. The first surface includes a central recess 120 and a pedestal 130 from which at least one microneedle extends, and the pedestal is not coplanar with the central dent. The platform substantially surrounds the central recess. At least one microneedle 160 includes a body having an outer surface 163, a base portion 166 having a base and a first shape, and a tip portion 168 having a second shape different from the tip 164 and the first shape, A main body is provided that includes a transition surface 167 that draws the base portion and the tip portion, and a central axis.少なくとも１つのマイクロニードル１６０を備える物品１００が提供される。本物品は、第１の面１１２と、第１の面と反対側の第２の面１１４とを備える。第１の面は、中央凹み部１２０と、少なくとも１つのマイクロニードルが延在する台部１３０とを備え、台部は、中央凹み部と同一平面上にない。台部は、中央凹み部を実質的に取り囲む。少なくとも１つのマイクロニードル１６０は、外表面１６３を備える本体と、基部及び第１の形状を有する基部部分１６６と、先端１６４及び第１の形状とは異なる第２の形状を有する先端部分１６８と、基部部分と先端部分を線引きする遷移面１６７と、中心軸と、を備える本体を備える。
