Dosage compensating transgenes and cells

• 收藏
• 分享

专利权人:

发明人:

Jeanne B. Lawrence,Jun Jiang,Lisa L. Hall

申请号：

US14215997

公开号：

US09681646B2

申请日:

2014.03.17

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/