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Formulations of azaindole compounds, processes of preparing same and uses thereof
专利权人:
VERTEX PHARMACEUTICALS INCORPORATED
发明人:
申请号:
IL24558716
公开号:
IL245587D0
申请日:
2016.05.10
申请国别(地区):
IL
年份:
2016
代理人:
摘要:
A pharmaceutical composition comprises: a) 5 wt% to 95 wt% of a HC1 salt*xH2O of Compound (1) by the weight of the pharmaceutical composition, wherein x is from 0 to 3 and b) 5 wt% to 95 wt% of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/mL to 20 mg/mL of Compound (1) in water and b) 0.01 M to 0.1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1) that includes the HC1 salt*xH2O of Compound (1) and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HC1 salt*xH2O of Compound (1) and the pH modifier to form 1 mg/mL to 20 mg/mL of Compound (1) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, and treating influenza each independently employ such pharmaceutical compositions.
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