Simone, Eric Arthur,Sanghvi, Tapan,Banda, Alamelu,Stavropoulos, Katherine
申请号：
AU2014348762
公开号：
AU2014348762A1
申请日:
2014.11.12
申请国别(地区):
AU
年份:
2016
代理人:
摘要：
A pharmaceutical composition comprises: a) 5 wt% to 95 wt% of a HC1 salt of Compound (1)·χΗ20 by the weight of the pharmaceutical composition, wherein x is from 0 to 3； and b) 5 wt% to 95 wt% of a filler by the weight of the pharmaceutical composition. Another pharmaceutical composition comprises: a) 1 mg/mL to 20 mg/mL of Compound (1) in water； and b) 0.01 M to 0.1 M of a pharmaceutically acceptable pH modifier. A method of preparing a pharmaceutical composition, comprising providing a mixture of Compound (1) that includes the HC1 salt of Compound (1)·χΗ20 and the filler. Another method of preparing a pharmaceutical composition comprises mixing the HC1 salt of Compound (1)·χ¾0 and the pH modifier to form 1 mg/mL to 20 mg/mL of Compound (1) in water. Methods of reducing the amount of influenza viruses, inhibiting the replication of influenza viruses, and treating influenza each independently employ such pharmaceutical compositions.
