The invention discloses a use of a Brazilian mushroom extract for preparing a pharmaceutical composition for inhibiting pulmonary fibrosis, wherein the Brazilian mushroom extract is an alcohol extract obtained by alcohol extraction from a Brazilian mushroom fruit body, or an alcohol extract. The separation and purification of the extracted extracts by macroporous adsorption resin, together with the pharmaceutically acceptable carrier, can be used as a pharmaceutical composition, in particular, can inhibit the proliferation of pulmonary fibroblasts, and at the same time, promote the promotion of pulmonary fibroblasts. Death, inhibition of lung cell activity and inhibition of lung tissue destruction will contribute to the prevention and treatment of pulmonary fibrosis.本發明揭露一種巴西蘑菇萃取物用於製備抑制肺纖維化之醫藥組合物的用途，其巴西蘑菇萃取物係為由巴西蘑菇子實體以酒精萃取所製得的酒精萃取物、或由酒精萃取物再經大孔吸附樹脂分離純化的萃取分離物，再搭配醫藥學上可接受之載劑作成醫藥組合物，特別能夠對於肺纖維母細胞的增生產生抑制作用，同時，可達到促進肺纖維母細胞死亡、抑制肺臟細胞活性及抑制肺臟組織結構的破壞，將有助於肺纖維化疾病的預防和治療。
