Humanized IL-6 and IL-6 receptor

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专利权人:

REGENERON PHARMACEUTICALS, INC.

发明人:

Wang Li-Hsien,Dore, Jr. Anthony T.,Stevens Sean,Murphy Andrew J.

申请号：

US201615350739

公开号：

US10004211(B2)

申请日:

2016.11.14

申请国别(地区):

美国

年份:

2018

代理人:

Scully, Scott, Murphy & Presser, P.C. `Goldberg Elysa

摘要：

Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Rα locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/