The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I):whereinRh and Ri are taken together to form a bond； Ra and Rb and/or Rd and Re are taken together to form oxo or the like； Rc is hydrogen, substituted or unsubstituted alkyl or the like；Rf is —(CR4aR4b)n—R2； R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like； R2 is substituted or unsubstjtuted cycloalkyl or the like； n is an integer of 1 to 4； —Rg is —X—R3； —X— is —O—, —S— or the like； R3 is substituted or unsubstituted cycloalkyl or the like,or its pharmaceutically acceptable salt or a solvate thereof.
