TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY农业专利-农业学术服务平台

发明人:: KAI, HIROYUKI,KAMEYAMA, TAKAYUKI,HORIGUCHI, TOHRU,ASAHI, KENTARO,ENDOH, TAKESHI,FUJII, YASUHIKO,SHINTANI, TAKUYA,NAKAMURA, KENICHIROH,JIKIHARA, SAE,HASEGAWA, TSUYOSHI,OOHARA, MIHO,TADA, YUKIO,MAKI, TO

摘要：: The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I):whereinRh and Rj are taken together to form a bond Ra and Rb and/or Rd and Re are taken together to form oxo or the like Rc is hydrogen, substituted or unsubstituted alkyl or the likeRf is -(CR4aR4b)n-R2 R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like R2 is substituted or unsubstituted cycloalkyl or the like n is an integer of 1 to 4 -Rg is -X-R3 -X- is -O-, -S- or the like R3 is substituted or unsubstituted cycloalkyl or the like,or its pharmaceutically acceptable salt or a solvate thereof.