New triazine derivatives and pharmaceutical compositions containing the same

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专利权人:

塩野義製薬株式会社

发明人:

甲斐 浩幸,亀山 貴之,長谷川 剛,大原 美穂,多田 幸男,遠藤 毅

申请号：

JP2010550529

公开号：

JP5692747B2

申请日:

2010.02.10

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The present invention provides a novel P2X 3 and/or P2X 2 / 3 receptor antago nist. A compound represented by the formula (I): wherein R a , R b and R c are, (a) R a and R b are taken together =Z； and R c is a group represented by R 1c ； or (b) R b and R c are taken together to form a bond； and R a is a group represented by -Y-R 1a ； R 1a and R 1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.； R 2 and R 3 are each independently substituted or unsubstituted aryl, etc.； R 4a and R 4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.； X is -N(R 5 )-, etc.； R 5 is hydrogen, substituted or unsubstituted lower alkyl, etc.； -Y- is -O-, etc.； =Z is =O, etc.； and n is an integer of 0 to 4.

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