ACIDES AMINÉS SPIROCYCLIQUES CYCLOPROPANIQUES ANALOGUE DE L'ACIDE -AMINO-OLÉIQUE À MOBILITÉ DE CONFORMATION LIMITÉE ET PRÉPARATIONS MÉDICINALES SUR LEUR BASE
The present invention relates to the field of organic and medicinal chemistry, and may also be used in applied medicine. The essence of the invention consists in that novel spirocyclic cyclopropanoic amino acids of general formula I, which are conformationally limited analogues of γ-aminobutyric acid, are proposed. In formula I, where n= 0-3 and Z=CR6R7, R1 - R7 are selected independently from a group consisting of hydrogen, (C1-C6)-alkyl and cyclo(C1-C6)-alkyl. These amino acids exhibit anti-psychotic, antidepressive, anti-spasmodic and anxiolytic properties. Drugs are also proposed for treating psychotic and depressive disorders, including for schizophrenia and affective dysfunctions； for treating convulsive conditions of varying genesis, including within the scope of epilepsy； for treating anxiety disorders of varying genesis, including generalized anxiety dysfunction and panic attacks； for treating somatoform dysfunctions, including persistent pain； for treating pain syndrome of varying genesis； for treating cognitive disorders, including attention and memory disorders of varying genesis.
