Refers to a compound of formula I, where the ring is a pyrazole ring, a pyrimidine ring and a Pyridine Ring X is CH2 or and R is a hydrogen Atom or c1-c6 alkyl.Preferred compounds are: acid ((2 - (3,5-bis (trifluoromethyl) phenyl) pyrimidin-5-yl) oxy) acetic acid acid ((6 - (3,5-bis (trifluoromethyl) phenyl) pyridin-3-yl) oxy) acetic acid, 3 - (3 - (3,5-bis (trifluoromethyl) phenyl) - 1H pyrazol-1-yl) propanoic acid among others. It also relates to a Pharmaceutical composition.These compounds possess reduction on the action of retinol Binding Protein 4 (RBP4), being useful in the treatment of age-related Macular Degeneration, Stargardts disease, among otherSe refiere a un compuesto de formula I, donde: el anillo A es un anillo pirazol, un anillo piridina o un anillo pirimidina X es CH2 u O y R es un atomo de hidrogeno o alquilo C1-C6. Son compuestos preferidos: acido ((2-(3,5-bis(trifluorometil)fenil)pirimidin-5-il)oxi)acetico acido ((6-(3,5-bis(trifluorometil)fenil)piridin-3-il)oxi)acetico acido 3-(3-(3,5-bis(trifluorometil)fenil)-1H-pirazol-1-il)propanoico entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos poseen accion de reduccion sobre la proteina de union a retinol 4 (RBP4), siendo utiles en el tratamiento de la degeneracion macular relacionada con la edad, enfermedad de Stargardt, entre otras
