COOK, BRIAN NICHOLAS,DISALVO, DARREN,FANDRICK, DANIEL ROBERT,HARCKEN, CHRISTIAN,KUZMICH, DANIEL,LEE, THOMAS WAI-HO,LIU, PINGRONG,MAO, CAN,NEU, JOCHEN,RAUDENBUSH, BRIAN CHRISTOPHER,RAZAVI, HOSSEIN,REEV
申请号：
NZ59111509
公开号：
NZ591115A
申请日:
2009.09.22
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is an azaindazole compound of formula (I) where the substituents are as disclosed in the specification. Examples of compounds of formula (I) are: 1-(4-Fluorophenyl)-1H-pyrazolo[3,4-c ]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide 1-(4-Fluorophenyl)-1H-pyrazolo[3 ,4-c ]pyridine-4-carboxylic acid (2-cyano-pyridin-4-ylmethyl)-amide 1-(4-Fluorophenyl)-6-oxy-1H-pyrazolo[3,4-c]pyridine-4-carboxylic acid 3-trifluoromethyl-benzylamide and 1-(4-Fluorophenyl)-6-methyl-4-(3-trifluoromethyl-benzylcarbamoyl)-1H-pyrazolo[3,4-c ]pyridin-6-ium iodide. The compounds are useful in treating chronic inflammation, allergies, contact dermatitis, psoriasis, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, inflammatory bowel disease, Guillain-Barre syndrome, Cohns disease, ulcerative colitis, graft versus host disease, Alzheimers disease, asthma, chronic kidney disease, sepsis, autoimmune myocarditis and systemic lupus erythematosus. Also disclosed is a pharmaceutical composition comprising a compound of formula (I), the use of a compound of formula (I) in the manufacture of a medicament and the process for preparing or synthesising a compound of formula (I).
