Indiana University Research and Technology Corporation
发明人:
Hamideh Zarrinmayeh,Mark Alan Green
申请号：
US16626723
公开号：
US20200123104A1
申请日:
2018.06.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Disclosed are P2X7 receptor ligands having the formula (I):in which R=—；(CH2)n—；(O—；CH2CH2)m—；Ol—；(CH2)p—；X, l=0-1, m=0-6, n=2-3, p=0-2, and X=Br, Cl, F or 18F. In illustrative embodiments, R=—；(CH2)n, and n=2-3. The receptor ligands are used in methods related to conditions related to the P2X7 receptor. The non-radioligands are useful for modulating inflammation conditions associated with the P2X7 receptor. The radioligands, containing 18F, are useful for as radiotracers in imaging processes, and thus for the detection and evaluation of inflammation and therapies. Also provided are processes for preparation of these P2X7 receptor ligands.
