The Invention provides a conjugate, or a pharmaceutically acceptable Salt thereof,Comprising a polypeptide Synthetic Formula I: Q - R - P - R - L - C - H - K - G - P - (NIE) - C - F (R) or an amide or Ester thereof and a selected Fatty Acid of formula I The Fatty Acid is covalently attached to the n-terminus of a Peptide by its features of acid Or carboxylic acid,Optionally through a Linker of polyethylene glycol and in which the two cysteine amino acids marked with \"\" forming a disulfide bond between the thiol functionalities of its side chain. The Conjugates are APJ receptor agonists.The Invention also relates to a method for Manufacturing the \u00b7invencion Conjugates and their Therapeutic uses, such as Treatment or prevention of acute decompensated Heart Failure (ICAD), Chronic Heart Failure, pulmonary hypertension, atrial fibrillation, without Brugada Syndrome, ventricular tachycardia, hypertension, atherosclerosis, restenosisIschemic cardiovascular diseases, cardiomyopathy, Cardiac fibrosis, arrhythmia, Water Retention (including diabetes, gestational diabetes, peripheral arterial disease, obesity, Stroke, transient ischemic attacks, Traumatic Brain Injury, sclerosis Amyotrophic lateral Burns (including sunburn) and preeclampsia.The present Invention also provides a combination of pharmacologically Active agents and a Pharmaceutical compositionLa invencion proporciona un conjugado, o una sal farmaceuticamente aceptable del mismo, que comprende un polipeptido sintetico de Formula I: Q-R-P-R-L-C -H-K-G-P-(NIe)-C -F (I) o una amida o ester del mismo y un acido graso seleccionado de: Formula I en el que dicho acido graso esta unido covalentemente al extremo N-terminal del peptido a traves de una de sus funcionalidades de acido carboxilico, opcionalmente a traves de un enlazador de polietilenglicol y en el que los dos aminoacidos de cisteina marcados con " " forman un enlace disulfuro entre las funcionalidades tiol de su cadena lateral. Los conjugados son agonis
