BOYLE, Robert George,WALKER, David Winter,BOYLE ROBERT GEORGE,WALKER DAVID WINTER
申请号：
CL2018000839
公开号：
CL2018000839A1
申请日:
2018.03.29
申请国别(地区):
CL
年份:
2018
代理人:
摘要：
The Invention provides a compound that Inhibits or modulates the activity of p70S6 kinase, compounds of formula (i) or a Salt,Tautómero N - Oxide or the same； where: one of y and Z is R3 and the other is a group alquileno ar2； Q1 is optionally substituted C1 - 8； and where a carbon Atom in the Group alquileno C1 - 8 May rEemplazarse optionally by a group ciclobutano dilaurate cyclopropane - 1,1 - or - 1, 1 - dilaurate,Provided that the total number of carbon Atoms in a group alquileno containing such replacement does not exceed 8； Q2 is a link or an optionally substituted C1 - 8 alquileno Group； r1 is selectedHydrogen, and a Group nrxry CY1, RX and ry are selected each between HydrogenHidrocarbilo c1-4 or hydroxy hidrocarbilo c1-4, or nrxry form a Heterocyclic Ring of 4 to 7 members optionally substituted； CY1) is a carbocíclico monocyclic Aromatic or Heterocyclic no 37 members optionally replaced, linked to C； R2 and R4 are each Hydrogen, Fluorine, Chlorine,C1-2 alkyl and alkoxy optionally substituted c1-2 optionally substituted； R3 is selected from Hydrogen, Fluorine, Chlorine,C1-2 alkyl and alkoxy optionally substituted c1-2 optionally substituted aryl； AR1 is a monocyclic heteroaryl Ring or of 5 or 6 members optionally substituted heteroaryl Group； and ar2 is aBicyclic or 8 to 11 members optionally substituted.The compounds are useful in Medicine, for example, in the treatment of a disease or condition selected from cancers, Developmental Disorders and Neurodegenerative Diseases.<；p>；La invenció；n proporciona un compuesto que inhibe o modula la actividad de la p70S6 quinasa, siendo los compuestos de fó；rmula (I) o una sal, tautó；mero o N-ó；xido de la misma； en donde: uno de Y y Z es R3 y el otro es Ar2； Q1 es un grupo alquileno C1-8 opcionalmente sustituido； y en donde un á；tomo de carbono del grupo alquileno C1-8 puede reemplazarse opcionalmente por un grupo ciclopropano-1,1-diilo o ciclobutano-1, 1-diilo, siempre que el n&uacu
