FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III
发明人:
PASTOR FERNANDEZ, JOAQUÍN,KURZ, GUIDO,MARTINEZ GONZALEZ, SONIA
申请号：
ES10715318
公开号：
ES2548571T3
申请日:
2010.04.01
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula I, ** Formula ** in which: R1 represents: (i) aryl substituted with one or more substituents selected from A1； or (ii) heteroaryl optionally substituted with one or more substituents selected from A2； R2 represents hydrogen or C1-3 alkyl optionally substituted with one or more fluorine atoms； R3 represents aryl or heteroaryl, each of which is optionally substituted with one or more substituents selected from A3 and A4, respectively； Each A1, A2, A3 and A4 represent independently, each time used herein: (i) Q1； (ii) C1-12 alkyl or heterocycloalkyl, each of which is optionally substituted with one or more substituents selected from>； = O,>； = S,>； = N (R10a) and Q2； or (iii) aryl or heteroaryl, each of which is optionally substituted with one or more substituents selected from Q3； each Q1, Q2 and Q3 independently represents, each time used herein: halo, -CN, - NO2, -N (R10a) R11a, -OR10a, -C (>； = Y) -R10a, -C ( >； = Y) -OR10a, -C (>； = Y) N (R10a) R11a, -OC (>； = Y) -R10a, -OC (>； = Y) -OR10a, - OC (>； = Y) N (R10a ) R11a, -OS (O) 2OR10a, -OP (>； = Y) (OR10a) (OR11a), -OP (OR10a) (OR11a), -N (R12a) C (>； = Y) R11a, - N (R12a ) C (>； = Y) OR11a, -N (R12a) C (>； = Y) N (R10a) R11a, -NR12aS (O) 2R10a, -NR12aS (O) 2N (R10a) R11a, -S (O) 2N (R10a) R11a, - SC (>； = Y) R10a, -SC (>； = Y) OR10a, -SC (>； = Y) N (R10a) R11a, -S (O) 2R10a, -SR10a, -S (O ) R10a, -S (O) 2OR10a, C1-12 alkyl, heterocycloalkyl (these last two groups being optionally substituted with one or more substituents selected from>； = O,>； = S,>； = N (R20) and E1), aryl or heteroaryl (these last two groups being optionally substituted with one or more substituents selected from E2)； each R10a, R11a and R12a independently represents, each time used herein, hydrogen, C1-12 alkyl, heterocycloalkyl (these last two groups being optionally substituted with one or more substituents selected from>； = O,>； = S, >； = N (R20) and E335), aryl or heteroaryl
