JADHAV, PRABHAKAR KONDAJI,SAEED, ASHRAF,GREEN, JONATHAN EDWARD,KRISHNAN, VENKATESH,MATTHEWS, DONALD PAUL,STEPHENSON, GREGORY ALAN
申请号：
PE2014000521
公开号：
PE20141669A1
申请日:
2012.10.05
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to a compound of formula I or a pharmaceutically acceptable salt, where n is 1-2； X is - CH2.- that is...R1 ES-CH3 O-CH2CH3-；R2 is - h-o-ch3, R3 is - h-u-oh, wherein R3 is - H,- oh The most popular compounds are: 2-Chloro-4 - [(1R, 2R) - 2-hydroxi-2-methyl-cyclopentanol] amine] - 3-methyl-benzoate； cis-2-chloro-4 - [[2-hydroxy-2-methyl-cyclopentanol] amine] - 3-methyl-benzoate； 2-Chloro-4 - [(1R, 2S) - 2-hydroxi-2-methyl-cyclopentanediol] amine] - 3-methyltrinitrate. This compound is the dying body of the AR (androgeno receiver),More specifically, it is a SARMs (selective androgeno receiver module). He also mentioned a pharmacological synthesis that is useful in the treatment of muscular atrophy.SE REFIERE A UN COMPUESTO DE FORMULA I O UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, DONDE: n ES 1-2； X ES -CH2-, -O-； R1 ES -CH3 O -CH2CH3-； R2 ES -H O -CH3； R3 ES -H U -OH, EN DONDE R3 ES -H , -OH. SON COMPUESTOS PREFERIDOS: 2-CLORO-4-[[(1R,2R)-2-HIDROXI-2-METIL-CICLOPENTIL]AMINO]-3-METIL-BENZONITRILO； CIS-2-CLORO-4-[[2-HIDROXI-2-METIL-CICLOPENTIL]AMINO]-3-METIL-BENZONITRILO； 2-CLORO-4-[[(1R,2S)-2-HIDROXI-2-METIL-CICLOPENTIL]AMINO]-3-METIL-BENZONITRILO； ENTRE OTROS.. DICHO COMPUESTO ES AGONISTA DE AR (RECEPTOR ANDROGENO), MAS ESPECIFICAMENTE ES UN SARMS (MODULADOR DE RECEPTOR DE ANDROGENO SELECTIVO). TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA QUE ES UTIL EN EL TRATAMIENTO DE LA ATROFIA MUSCULAR.
