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Phenanthroindolizidine derivative and NFκB inhibitor containing same as active ingredient
专利权人:
Takashi Yaegashi;Takashi Ikeda;Ryuta Yamazaki;Seigo Sawada;Shusuke Hashimoto;Takeshi Matsuzaki
发明人:
Takashi Ikeda,Seigo Sawada,Takashi Yaegashi,Takeshi Matsuzaki,Shusuke Hashimoto,Ryuta Yamazaki
申请号:
US13124554
公开号:
US08569327B2
申请日:
2009.10.23
申请国别(地区):
US
年份:
2013
代理人:
摘要:
A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, or the like;R2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the like;R3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atom;R4 represents a hydrogen atom or a lower alkyloxy group;R5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6;R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5;R7 represents a hydrogen atom or a lower alkyl group; andR8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.
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