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PHENANTHROINDOLIZIDINE DERIVATIVE AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
专利权人:
发明人:
申请号:
EP09821826.6
公开号:
EP2351753B1
申请日:
2009.10.23
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
A novel compound having an excellent NFκB inhibitory effect is provided. Specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, or the likeR2 represents a hydrogen atom, a lower alkyl group, a halogen atom, or the likeR3 represents a hydrogen atom, a lower alkyl group, a hydroxyl group, or a halogen atomR4 represents a hydrogen atom or a lower alkyloxy groupR5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5R7 represents a hydrogen atom or a lower alkyl group andR8 represents a hydrogen atom, a hydroxyl group, an amino group, a lower alkylcarbonyloxy group, or a halogen atom.
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