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PHENANTHROINDOLIZIDINE COMPOUND AND NF kB INHIBITOR CONTAINING SAME AS ACTIVE INGREDIENT
专利权人:
发明人:
申请号:
EP09821827.4
公开号:
EP2351754B1
申请日:
2009.10.23
申请国别(地区):
EP
年份:
2015
代理人:
摘要:
A novel compound having an excellent NFκB inhibitory effect is provided and specifically disclosed is a compound represented by the following formula (1) or a salt thereof:wherein, R1 represents a hydrogen atom, a lower alkyl group, a lower alkyloxy group, or a halogen atomR2 represents a hydroxyl group, or a lower alkyloky groupR3 represents a hydrogen atom, a lower alkyl group, or a halogen atomR4 represents a hydrogen atom or a lower alkyloxy groupR5 represents a hydrogen atom, a lower alkyloxy group, a halogen atom, a hydroxyl group, or a methylenedioxy group formed together with R6 or an isopropylidenedioxy group formed together with R6R6 represents a hydrogen atom, a lower alkyloxy group, or a methylenedioxy group formed together with R5 or an isopropylidenedioxy group formed together with R5R7 represents a hydrogen atom or a lower alkyl group andR8 represents a hydrogen atom, a hydroxyl group, an amino group, or a lower alkylcarbonyloxy group (excluding the case where R1, R3, R4 and R7 are hydrogen atoms, R2 and R8 are hydroxyl groups, and R5 and R6 are methoxy groups).
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