FORMULATIONS D'INTERFERON BETA EXEMPTES D'ALBUMINE SERIQUE HUMAINE

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专利权人:

CHIRON CORPORATION

发明人:

SHIRLEY, BRET A.,CHOE, MINNA,TELLERS, MELANIE,BABUKA, SUSAN,CHEN, BAO-LU,HORA, MANINDER

申请号：

CA2442854

公开号：

CA2442854C

申请日:

2001.10.26

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

Stabilized pharmaceutical compositions comprising substantially monomericinterferon-beta (IFN-.beta.) and methods useful in their preparation areprovided. The compositions comprise the IFN-.beta. solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 5Ømethods for preparing these compositions, and for increasing solubility of IFN-.beta. in pharmaceutical compositions, are provided.

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