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UDOSKONALONE PREPARATY I SPOSOBY LIOFILIZACJI ORAZ UZYSKIWANE LIOFILIZATY
专利权人:
Biogen Chesapeake LLC
发明人:
JACOBSON, MARTIN SVEN
申请号:
PL14188334
公开号:
PL2868315T3
申请日:
2008.12.03
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
The present invention provides compositions, methods for lyophilizing compounds and making pharmaceutical compositions, and kits providing solutions and lyophilized formulations of compounds. The compositions, methods, and kits are particularly useful in pharmaceutical applications involving therapeutic agents that have low solubility at low pH and medium pll values. Certain embodiments provide methods for lyophilizing compounds in liquid solutions, which include the steps of: a) preparing aqueous solutions of a compound of interest in the absence of buffer; b) adjusting the pH to high values of pH in order to increase the solubility of the compound of interest; and c) frecze-drying the solution to provide a lyophilized solid composition. Aqueous solutions including buffer are also disclosed. Lyophilized formulations, including micronized and non-micronized powders, are provided.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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