University of Florida Research Foundation, Inc.;University of Florida Research Foundation;Université de Liège; Inc.
发明人:
LORIA, Rosemary,JOURDAN, Samuel,RIGALI, Sebastien,FRANCIS, Isolde, Maria
申请号：
EP15841965
公开号：
EP3214933A4
申请日:
2015.09.17
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in some aspects, relate to genetically modified Streptomyces bacteria capable of increased thaxtomin production, genetically modified Streptomyces bacteria with reduced activity of a CebR protein encoded by a cebR gene and/or reduced activity of a β-glucosidase enzyme encoded by the bglC gene, genetically modified Streptomyces bacteria including a mutation of a native cebR gene and/or a native bglC gene, methods of increasing thaxtomin production in Streptomyces bacteria, methods of suppressing CebR and/or BglC activity, methods of producing thaxtomin, and thaxtomin produced by the methods of the present disclosure.
