University of Florida Research Foundation, Inc.;UNIVERSITE DE LIEGE
发明人:
Rosemary Loria,Samuel Jourdan,Sebastien Rigali,Isolde Maria Francis
申请号：
US15510863
公开号：
US10385372B2
申请日:
2015.09.17
申请国别(地区):
US
年份:
2019
代理人:
摘要：
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in some aspects, relate to genetically modified Streptomyces bacteria capable of increased thaxtomin production, genetically modified Streptomyces bacteria with reduced activity of a CebR protein encoded by a cebR gene and/or reduced activity of a β-glucosidase enzyme encoded by the bglC gene, genetically modified Streptomyces bacteria including a mutation of a native cebR gene and/or a native bglC gene, methods of increasing thaxtomin production in Streptomyces bacteria, methods of suppressing CebR and/or BglC activity, methods of producing thaxtomin, and thaxtomin produced by the methods of the present disclosure.
