An incision simulation device includes a processor, in which the processor acquires an incision line for a three-dimensional organ image showing an organ which is an incision simulation target, and specifies an incision region from the three-dimensional organ image based on an incision process position between the incision line and a maximum incision region, first distance data with the incision line as a reference, and second distance data with the maximum incision region designated for the three-dimensional organ image as a reference.