Provide blood product of the method and system automatically removing air from collection vessel. The system includes that disposable flow circuits include the pipe being in fluid communication, collection vessel and durable hardware component. Flow target product on first/forward direction of the pump of programmable controller operation enters collection vessel Determine that essentially all target product is pumped into collection vessel Enter collection vessel with pump tracking air capacity on first/forward direction of pump operation and remains in pipe together with any target product. In one embodiment, be pumped into collection vessel in tracking air, second/inverse direction of controller pump operation by air from collection vessel, and the operating of pump, when air is substantially equal to from collection vessel the air of residual volume.
