David H. Coy;Cyril Y. Bowers;Simon J. Hocart;Gloria S. Tannenbaum
发明人:
Cyril Y. Bowers,David H. Coy,Simon J. Hocart,Gloria S. Tannenbaum
申请号：
US13320408
公开号：
US20120135918A1
申请日:
2010.05.12
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A11-A12-A13-Gly-Ser-A14-Phe-Leu-A15-A16-A17-A18, wherein each of A11, A12, and A13 is independently absent, an amino acid, or an amino protecting group； each of A15-A16-A17, and A18 is independently absent or an amino acid； and A14 is a serine conjugated with a —C(O)C1-C20alky or a di-aminopropionic acid conjugated with a —C(O)C1-C20alkyl group, provided that at least one of A11, A12, or A13 is present.
