Cyril Y. BOWERS,David H. COY,Simon J. HOCART,Gloria S. TANNENBAUM
申请号：
US14505101
公开号：
US20150031605A1
申请日:
2014.10.02
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides methods for treatment, prevention or management of obesity, obesity related disorders, diabetes mellitus, and metabolic syndrome in a subject by administering a ghrelin O-acyltransferase (GOAT) inhibitor and/or a ghrelin receptor antagonist to the subject. The invention also provides ghrelin receptor antagonists of formula (VII): A11-A12-A13-Gly-Ser-A14-Phe-Leu-A15-A16-A17-A18, wherein each of A11, A12, and A13 is independently absent, an amino acid, or an amino protecting group each of A15, A16, A17, and A18 is independently absent or an amino acid and A14 is a serine conjugated with a —C(O)C1-C20alky or a diaminopropionic acid conjugated with a —C(O)C1-C20alkyl group, provided that at least one of A11, A12, or A13 is present.
