FORMULATION PHARMACEUTIQUE NASALE DE TESTOSTÉRONE ET « KIT » SOUS FORME DE TABLETTE DE DISPOSITIFS NASAUX UNITAIRES POUR APPLICATION DE MONODOSE DE TESTOSTÉRONE
DE OLIVEIRA NETO, Moisés Alves,REZENDE, Brandão De Souza,PERILLO, Marcelo Reis
申请号：
BRBR2016/050212
公开号：
WO2017/035619A1
申请日:
2016.08.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
The invention relates to a nasal pharmaceutical testosterone formulation and of a series of devices that form a packaging card-shaped pharmaceutical kit for nasal administration of testosterone, the kit being formed by a plurality of therapeutically measured single doses or monodoses. The series of devices that form the pharmaceutical kit is characterised by a series of individual devices (1) containing a micronised testosterone gel formulation of high viscosity, with a low hormone dosage, providing to a female or male patient precisely measured and physiologically suitable testosterone unit doses. After use, the device is immediately discarded by the user, without residual hormone losses even during nasal administration, in view of the high viscosity of the formulation which, together with the air pumping device for the medicinal drug contained in the device, ensures the release of practically all the content of the device. Each device comprises a hollow chamber (2) containing the medicinal drug, and an air column zone that acts as a plunger to expel the volume of medicinal drug contained in the chamber (2). The air expulsion chamber (3) provides air compressed by the user inside the hollow chamber (2), which acts as compressed air when it is pressed through the neck (6) located between the hollow chamber (2) and the air chamber (3). Predetermined tearing lines (8 - 9 - 12) make it easier to remove each device from the packaging card before use.L'invention concerne une formulation pharmaceutique nasale de testostérone et un ensemble de dispositifs constituant un kit pharmaceutique sous forme de tablette, destiné à l'administration de testostérone par voie nasale, formé d'une pluralité de dispositifs d'application d'une dose unique ou monodose, mesurée thérapeutiquement. L'ensemble de dispositifs constituant le kit pharmaceutique est caractérisé par un ensemble de dispositifs individuels (1) contenant une formulation en gel à base de testostérone micronisée, à haute
