A method produces a number of medicaments with a predetermined active substance and for simultaneously making an active substance value indicating the active substance quantity contained in the medicament available. A standard value is determined for the active substance quantity of the medicaments and a maximum deviation from the standard value is predefined. An active substance value is selected within an interval cN+/−Δc or predefined and an active substance quantity is used as a reference for the preparation of the respective medicament which quantity matches the active substance value. The active substance value established is associated with the medicament and is held available together with the medicament once the medicament is prepared.